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Plaque-identifying toothpaste could reduce risk of heart disease and stroke

By Dental Tribune International
October 21, 2016

BOCA RATON, Fla., USA: Health experts worldwide agree that oral health and inflammatory diseases, such as cardiovascular disease and stroke, are correlated. A recently published study has shown that users of a toothpaste that identifies plaque buildup on teeth also exhibited lower levels of a heart disease marker, suggesting that the toothpaste resulted in statistically significant reductions in dental plaque and inflammation throughout the body.

In the study, 61 healthy individuals (aged 19–44) were randomly divided into two groups. While one group (31) used the plaque-identifying toothpaste for 60 days, the second group (30) used a placebo toothpaste for the same duration. To assess dental plaque, all participants utilized a fluorescein mouthrinse and intraoral photographs were taken under black light imaging.

An analysis showed that the plaque-identifying toothpaste reduced the mean plaque score by 49 percent compared with a 24 percent reduction in the placebo group. In addition, laboratory tests in a pre-specified subgroup of 38 participants found that the plaque-identifying toothpaste reduced levels of high-sensitivity C-reactive protein (hs-CRP), a sensitive marker for future heart attacks and strokes, by 29 percent, while hs-CRP levels increased by 25 percent in individuals using the placebo toothpaste.

Plaque HD, the toothpaste used in this study, was introduced at the beginning of 2016. It incorporates Targetol Technology, which contains all-natural, plant-based disclosing agents, and colors any plaque and thus helps users remove up to four times more plaque than standard toothpastes do.

The researchers concluded that the observed reduction supports the hypothesis that Plaque HD could reduce the risk of cardiovascular disease. However, a large-scale randomized trial of sufficient size and duration is needed to verify the results, they stated.

The study, titled “Randomized trial of plaque identifying toothpaste: Dental plaque and inflammation,” was published online on Oct. 19 in the American Journal of Medicine ahead of print. It was conducted at Florida Atlantic University in the U.S.

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